In my day-to-day life, EDS or cataplexy in narcolepsy
How much does EDS or cataplexy in
narcolepsy impact your day-to-day life?
What is your top goal for managing your EDS or
cataplexy in narcolepsy?
How often do you feel you reach this goal?

When it comes to my treatment plan, I am
How satisfied are you with your current
treatment plan?
How ready are you to consider a change to
your treatment?

My Questions About WAKIX^® (pitolisant)
How does WAKIX work? Is WAKIX a stimulant? Is WAKIX a controlled substance?	How is WAKIX taken? How long might it take for WAKIX to work? What are the possible side effects of WAKIX? Do you think WAKIX might be a treatment option for me?

Indications and Usage

WAKIX is a prescription medicine used to treat excessive daytime sleepiness (EDS) or sudden onset of weak or
paralyzed muscles (cataplexy) in adults with narcolepsy.

Important Safety Information

Do not take WAKIX if you are allergic to pitolisant or any
ingredient in WAKIX, or if you have severe liver disease.

Please see Important Safety Information
continued on following page and
accompanying Full Prescribing Information.

Important Safety Information (continued)

Tell your healthcare provider about all your medical conditions, including if you have heart rhythm irregularities, were born with a heart condition, or the levels of electrolytes in your blood are too high or too low. WAKIX^® (pitolisant) has an effect on the electrical activity of the heart known as QT prolongation. Medicines with this effect can lead to disturbances in heart rhythm, which are more likely in patients with risk factors such as certain heart conditions, or when taken in combination with other medicines that affect QT. Tell your healthcare provider about all the other medicines you take.

The risk of QT prolongation may be greater in patients with liver or kidney disease. WAKIX is not recommended in patients with end-stage kidney disease.

The most common side effects seen with WAKIX were insomnia, nausea, and anxiety. Other side effects included headache, upper respiratory tract infection, musculoskeletal pain, heart rate increased, and decreased appetite. These are not all the possible side effects of WAKIX. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Tell your healthcare provider about all the medicines you take or plan to take, including prescription and over-the-counter medicines. Some medicines can increase the amount of WAKIX that gets into your blood and some medicines can decrease the amount of WAKIX that gets into your blood. The dosage of WAKIX may need to be adjusted if you are taking these medicines.

WAKIX can also decrease the effectiveness of some medicines, including hormonal birth control methods. You should use an alternative non-hormonal birth control method during treatment with WAKIX and for at least 21 days after discontinuation of treatment.

Tell your healthcare provider if you are pregnant or planning to become pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women who are exposed to WAKIX during pregnancy. You are encouraged to enroll in the WAKIX pregnancy registry if you become pregnant while taking WAKIX. To enroll or obtain information from the registry, call 1-800-833-7460.

The safety and effectiveness of WAKIX have not been established in patients less than 18 years of age.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You can also report negative side effects to Harmony Biosciences at 1-800-833-7460.

Please see accompanying Full Prescribing Information.