How is WAKIX Taken?
WAKIX® (pitolisant) tablets are taken once daily in the morning, as soon as you wake up.
- If you miss a dose, take the next dose the following morning as soon as you wake up. If you have any questions, talk with your healthcare provider.
The recommended dosage range for WAKIX is 17.8 mg to 35.6 mg once daily.
Your healthcare provider will start you at a lower dose and may increase it each week to find the dose that's right for you. This process is called titration.
Titration can take time, but it's important for you and your healthcare provider to find the dose that's right for you.
Always take WAKIX exactly as your healthcare provider has prescribed.
What should I expect with WAKIX?
When starting a medication, especially one for a chronic disorder like narcolepsy, it is important to talk to your healthcare provider so he or she can help you understand what to expect with treatment.
Here are a few things for you to discuss with your healthcare provider about what to expect when taking WAKIX.
WAKIX is not a stimulant.
Everyone responds to medication differently. It's important to know that WAKIX may take some time to work, and for some patients, it may take up to 8 weeks to achieve a response.
Talk to your healthcare provider about how you are feeling after starting WAKIX.
- Ask them to explain how WAKIX works and how to know if you're responding to treatment.
- Tell them about any improvements you notice as well as any potential side effects.
- Don't stop or change the dose on your own without talking to your healthcare provider first.
- Your doctor may be able to adjust your dose of WAKIX to find a dose that works best for you.
What else should I know about WAKIX?
In a study where WAKIX was taken with sodium oxybate or modafinil, there were no significant changes in how their bodies processed these medications.
Tell your healthcare provider about all the medicines you take or plan to take.
WAKIX may reduce the effectiveness of hormonal contraceptives (birth control).
Women who can become pregnant should use an alternative non-hormonal type of birth control while taking WAKIX and for at least 21 days after discontinuation of treatment.
You are encouraged to enroll in the WAKIX Pregnancy Registry if you are pregnant and taking WAKIX or have taken WAKIX at any time during your pregnancy. This voluntary registry helps researchers learn more about the safety of WAKIX when used during pregnancy.
WAKIX is the only FDA-approved treatment for EDS or cataplexy in narcolepsy that is not a controlled substance.
A controlled substance is a drug or chemical that is regulated by the government based on its potential for abuse and dependence.
WAKIX personal stories
Hear the personal stories of real people living with narcolepsy. Each person has their own story to tell, from diagnosis to finding support, and their experience with WAKIX.Watch more
Indications and usage & Important Safety Information
Important Safety Information
Do not take WAKIX if you are allergic to pitolisant or any ingredient in WAKIX, or if you have severe liver disease.
Tell your healthcare provider about all your medical conditions, including if you have heart rhythm irregularities, were born with a heart condition, or the levels of electrolytes in your blood are too high or too low. WAKIX has an effect on the electrical activity of the heart known as QT/QTc prolongation. Medicines with this effect can lead to disturbances in heart rhythm, which are more likely in patients with risk factors such as certain heart conditions, or when taken in combination with other medicines that affect QT. Tell your healthcare provider about all the other medicines you take.
The risk of QT prolongation may be greater in patients with liver or kidney disease. WAKIX is not recommended in patients with end-stage kidney disease.
The most common side effects seen with WAKIX were insomnia, nausea, and anxiety. Other side effects included headache, upper respiratory infection, musculoskeletal pain, heart rate increased, and decreased appetite. These are not all the possible side effects of WAKIX. Tell your healthcare provider about any side effect that bothers you or that does not go away.
Tell your healthcare provider about all the medicines you take or plan to take, including prescription and over-the-counter medicines. Some medicines can increase the amount of WAKIX that gets into your blood and some medicines can decrease the amount of WAKIX that gets into your blood. The dosage of WAKIX may need to be adjusted if you are taking these medicines.
WAKIX can also decrease the effectiveness of some medicines, including hormonal birth control methods. You should use an alternative non-hormonal birth control method during treatment with WAKIX and for at least 21 days after discontinuation of treatment.
Tell your healthcare provider if you are pregnant or planning to become pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women who are exposed to WAKIX during pregnancy. You are encouraged to enroll in the WAKIX pregnancy registry if you become pregnant while taking WAKIX. To enroll or obtain information from the registry, call 1-800-833-7460.
The safety and effectiveness of WAKIX have not been established in patients less than 18 years of age.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You can also report negative side effects to Harmony Biosciences at 1-800-833-7460.
Please see Full Prescribing Information.
Indications and Usage
WAKIX is a prescription medicine used to treat excessive daytime sleepiness (EDS) or sudden onset of weak or paralyzed muscles (cataplexy) in adults with narcolepsy.
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