Starting WAKIX | WAKIX® (pitolisant) tablets

Starting WAKIX

Take WAKIX as soon as you wake up

WAKIX® (pitolisant) tablets are taken once daily in the morning, as soon as you wake up.

  • If you miss a dose, take the next dose the following morning as soon as you wake up.

WAKIX dosing

The recommended dosage range for WAKIX is 17.8 mg to 35.6 mg once daily.

  • Your healthcare provider may increase your dose each week to find the right dose for you. This process is called titration.

Always take WAKIX exactly as your healthcare provider has prescribed.

Sample dosing schedule

Week 1

8.9 mg once daily (two 4.45-mg tablets)

Week 2

17.8 mg once daily (one 17.8-mg tablet)

Week 3

May increase to 35.6 mg once daily
(two 17.8-mg tablets)

Beyond Week 3

Continue to take WAKIX as your
healthcare provider has prescribed

Tablets not actual size

Talk to your healthcare provider

It is important to tell your healthcare provider about your medical history when starting a new medication.

Your healthcare provider may prescribe WAKIX differently depending on your specific needs.

Tell your healthcare provider if you:

  • have heart, liver, or kidney problems

  • are taking other medications

  • have responded differently to other medications in the past

Tell your healthcare provider if you are pregnant or planning to become pregnant.

There is a pregnancy exposure registry that monitors pregnancy outcomes in women who are exposed to WAKIX during pregnancy. You are encouraged to enroll in the WAKIX pregnancy registry if you become pregnant while taking WAKIX. To enroll or obtain information from the registry, call 1-800-833-7460.

What should I expect when I take WAKIX?

When starting a new medication, especially one for a chronic disorder like narcolepsy, it is important to talk to your healthcare provider so he or she can help you understand what to expect with treatment.

Here are a few things for you to discuss with your healthcare provider when starting WAKIX.

  • It may take up to 8 weeks for some patients to notice a response to treatment with WAKIX.

    • Ask your healthcare provider to explain how WAKIX works and how to know if you're responding to treatment.

  • WAKIX is not a stimulant.

  • Talk to your healthcare provider about how you are feeling after starting WAKIX.

    • Tell your healthcare provider about any improvements you notice as well as any potential side effects. Don’t stop or change the dose on your own without talking to your healthcare provider first.

Find support specifically
for people taking WAKIX

Start here >

Get more helpful information

Sign up now >

Indications and usage & Important Safety Information

Important Safety Information

Do not use WAKIX if you have severe liver disease.

Tell your healthcare provider about all your medical conditions, including if you have heart rhythm irregularities, were born with a heart condition, or the levels of electrolytes in your blood are too high or too low. WAKIX has an effect on the electrical activity of the heart known as QT/QTc prolongation. Medicines with this effect can lead to disturbances in heart rhythm, which are more likely in patients with risk factors such as certain heart conditions, or when taken in combination with other medicines that affect QT. Tell your healthcare provider about all the other medicines you take.

The risk of QT prolongation may be greater in patients with liver or kidney disease. WAKIX is not recommended in patients with end-stage kidney disease.

The most common side effects seen with WAKIX were insomnia, nausea, and anxiety. Other side effects included headache, upper respiratory infection, musculoskeletal pain, heart rate increased, and decreased appetite. These are not all the possible side effects of WAKIX. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Tell your healthcare provider about all the medicines you take or plan to take, including prescription and over-the-counter medicines. Some medicines can increase the amount of WAKIX that gets into your blood and some medicines can decrease the amount of WAKIX that gets into your blood. The dosage of WAKIX may need to be adjusted if you are taking these medicines.

WAKIX can also decrease the effectiveness of some medicines, including hormonal birth control methods. You should use an alternative non-hormonal birth control method during treatment with WAKIX and for at least 21 days after discontinuation of treatment.

Tell your healthcare provider if you are pregnant or planning to become pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women who are exposed to WAKIX during pregnancy. You are encouraged to enroll in the WAKIX pregnancy registry if you become pregnant while taking WAKIX. To enroll or obtain information from the registry, call 1-800-833-7460.

The safety and effectiveness of WAKIX have not been established in patients less than 18 years of age.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You can also report negative side effects to Harmony Biosciences, LLC at 1-800-833-7460.

Please see Full Prescribing Information.

Indications and Usage

WAKIX is a prescription medicine for the treatment of excessive daytime sleepiness (EDS) in adult patients with narcolepsy.

Indications and usage & Important Safety Information

Important Safety Information

Do not use WAKIX if you have severe liver disease.

Tell your healthcare provider about all your medical conditions, including if you have heart rhythm irregularities, were born with a heart condition, or the levels of electrolytes in your blood are too high or too low. WAKIX has an effect on the electrical activity of the heart known as QT/QTc prolongation. Medicines with this effect can lead to disturbances in heart rhythm, which are more likely in patients with risk factors such as certain heart conditions, or when taken in combination with other medicines that affect QT. Tell your healthcare provider about all the other medicines you take.

The risk of QT prolongation may be greater in patients with liver or kidney disease. WAKIX is not recommended in patients with end-stage kidney disease.

The most common side effects seen with WAKIX were insomnia, nausea, and anxiety. Other side effects included headache, upper respiratory infection, musculoskeletal pain, heart rate increased, and decreased appetite. These are not all the possible side effects of WAKIX. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Tell your healthcare provider about all the medicines you take or plan to take, including prescription and over-the-counter medicines. Some medicines can increase the amount of WAKIX that gets into your blood and some medicines can decrease the amount of WAKIX that gets into your blood. The dosage of WAKIX may need to be adjusted if you are taking these medicines.

WAKIX can also decrease the effectiveness of some medicines, including hormonal birth control methods. You should use an alternative non-hormonal birth control method during treatment with WAKIX and for at least 21 days after discontinuation of treatment.

Tell your healthcare provider if you are pregnant or planning to become pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women who are exposed to WAKIX during pregnancy. You are encouraged to enroll in the WAKIX pregnancy registry if you become pregnant while taking WAKIX. To enroll or obtain information from the registry, call 1-800-833-7460.

The safety and effectiveness of WAKIX have not been established in patients less than 18 years of age.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You can also report negative side effects to Harmony Biosciences, LLC at 1-800-833-7460.

Please see Full Prescribing Information.

Indications and Usage

WAKIX is a prescription medicine for the treatment of excessive daytime sleepiness (EDS) in adult patients with narcolepsy.

CLOSE

You are now leaving the patient site.

This information is intended only for US healthcare professionals. If you are a healthcare professional, click “I agree” to continue.